Sunday, 13 July 2014

Insulin-like proteins

Relaxins . The predominant form of relaxin in the blood is a relaxin-2. Relaxin-3 is expressed exclusively in the brain. Relaxin-1 deficiency in mice leads to the development of progressive tissue fibrosis

that is accompanied by disturbances of the heart and lungs. Relaxin-2 deficiency leads to stunted growth and underdevelopment of the reproductive tract. Relaxins have vasodilator and pro-angiogenic effect, regulate the heart's activity.

INSL3-expressing cells Lyay Diga testes. Mutation or gene knockout INSL3 or LGR8 Pu in male mice leads to the blockade of testicular descent and development of cryptorchidism  

. Overexpression of INSL3 in females causes lowering of ovarian development of elements of the external genitalia of male type, reduced fertility. Information about the role of mutations in the development of cryptorchidism INSL3 in humans have been reported in 2-5% of newborn boys are contradictory.

 found in the placenta, uterus, perichondrium fruits secreted into the amniotic fluid and maternal blood in the placenta and stimulates the production of hCG is important for bone development of the fetus.

INSL5 found in the rectum and colon, and uterus. Expected to participate in the regulation of INSL5 intestinal motility. INSL6 expressed spermatocytes and spermatids of the seminiferous tubules.

Thymus peptides

Thymus - center (primary) lymphoid organ systems where the differentiation of T lymphocytes, occurring under the control of a variety of endo-, para-and autocrine factors, some of which are relatively specific to the thymus.

Thymopoietin and (3 and y - alternative splicing products having molecular weights of 75, 51 and 39 kDa, respectively. ubiquitously expressed, predominantly

  localized in the inner membrane and the nuclear membrane plays an important role in the architecture and operation of the cell nucleus and interacts with chromatin type lamins V.  

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